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    DEMETZOS LAB    

The Laboratory of Pharmaceutical Nanotechnology (Demetzos Lab) belongs to the Section of Pharmaceutical Technology of the Department of Pharmacy of the School of Health Sciences, National and Kapodistrian University of Athens (UoA). It is oriented in the area of applied nanotechnology, especially targeted drug delivery nanosystems and colloidal nanocarriers for therapeutic purposes. The lab has been and continues to be a participant in many international, european and national research programs. It is also in close collaboration with scientists and academic partners from institutions all over the world, as well as with a number of industries, aiming to produce scientific evidence that will aid the development and approval of innovative nanoproducts. It is also an active member of many scientific societies. Its director is Professor Costas Demetzos.

  

 

 

Recent News

 

COSTAS N. DEMETZOS

PROFESSOR

ACADEMY OF ATHENS 2018 AWARD

 

Costas N. Demetzos, Professor of Pharmaceutical Technology & Nano-Technology, Department of Pharmacy of the National & Kapodistrian University of Athens, was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology. The ceremony took place during the formal sitting on the 21th of December, 2018 in the Great ceremony hall of the Academy of Athens, after the unanimous decision of the Athens Academy Plenary. The President of the Academy of Athens, Academician Antonios Kounadis presented the award to the honored Professor.

 

 

 

Νέο Βιβλίο του Καθηγητή Κ. Δεμέτζου

Κυκλοφορεί από τις Εκδόσεις Παρισιάνου

 

Ο συγγραφέας περιγράφει με λογοτεχνικό τρόπο την ‘συνομιλία’ ανάμεσα στον μικρόκοσμο και στον μακρόκοσμο μέσα από μια φανταστική συζήτηση ενός νεαρού επιστήμονα με τον ‘παππού’ και τον φανταστικό ‘καθρέφτη’ της αυτογνωσίας. Η συζήτηση εξελίσσεται μέσα σε μια βιβλιοθήκη και βασίζεται στα σημαντικά επιτεύγματα της επιστήμης αλλά και της φιλοσοφίας τα οποία ο νεαρός επιστήμονας προσπαθεί να κατανοήσει. Ο συγγραφέας προσπαθεί να μεταφέρει μέσω της συζήτησης, την εξέλιξη των φυσικών νόμων που συμβαίνουν στον μικρόκοσμο, ως τα αληθινά ‘γεγονότα’ τα οποία εμείς προσπαθούμε να κατανοήσουμε στον μακρόκοσμο, με βάση τα επιστημονικά εργαλεία και την φιλοσοφική σκέψη που διαχρονικά έχουμε κατακτήσει ως ανθρώπινα όντα. Η συζήτηση είναι ελκυστική και βαθιά επιστημονική με αναφορές στην βιοφυσική και βιο-θερμοδυναμική, στην χημεία και στην πολυπλοκότητα των βιο-συστημάτων και βιο-δικτύων, ενώ η φιλοσοφία λειτουργεί ως εργαλείο ανάδειξης των ανθρώπινων αδυναμιών μας να κατανοήσουμε την έννοια της δημιουργίας και της κτίσης. Η κοινωνία ως αποδέκτης όλων των μεταβολών και εξελίξεων του μικρόκοσμου αποτελεί την αρένα της εξέλιξης των ‘γεγονότων’ του μικρόκοσμου στον μακρόκοσμο. Μια συνεχής και αέναη προσπάθεια χωρίς τέλος προτείνεται από τον συγγραφέα για την κατάκτηση της επιστημονικής γνώσης και της δημιουργικής προσφοράς του ανθρώπου στην κοινωνία και στον συνάνθρωπο.

 

 

 

Honorary Award to Professor Costas Demetzos
Best in Pharmacy Awards 2019

 

Honorary Best in Pharmacy award from Boussias Communications and from the journal Pharmaceutical World to Professor Costas Demetzos for his significant contribution in the Pharmaceutical Science.

 

 

 

PhD Thesis Presentation and Graduation of Nikolaos Naziris

 

Nikolaos Naziris, Pharmacist, MSc, was granted the title of Doctor of Philosophy in Pharmaceutical Sciences with the highest honors on July 15th. His PhD research regards the "Design, Technological Development and Evaluation of Stimuli-responsive Chimeric Nanocarriers for Cancer Therapy".

 

 

Honorary Award Ceremony to Professor Costas Demetzos
14th PanCretan Pharmaceutical Congress

 

Honorary award with gratitude, from the Pharmaceutical Associations of Crete to Professor Costas Demetzos for his significant contribution and recognition in Pharmaceutical Science, in Greece and internationally. The ceremony took place during the 14th PanCretan Pharmaceutical Congress in Sisi of Lasithi, Crete, Greece, May 2019.

In the picture, we may see from left to right I. Tsikandalakis, M. Fouledakis, Prof. C. Demetzos, K. Kaldis and K. Vardiabasis.

 

 

 

 

Latest Publications


 

In the present work, the convergence of two different drug delivery systems is investigated, namely the combination of carbon nanohorns (CNHs) and liposomes. Our effort initially included the synthesis of two conversely charged carbon nanohorns and their subsequent analysis through various methods. The study of their effect on the thermotropic behavior of artificial membranes provided an essential assistance for the upcoming liposome preparation, which were estimated for their physicochemical properties. The presence of CNHs alters the calorimetric parameters of the lipids. We also prepared CNHs:liposome systems. The characteristic morphology and secondary spherical superstructure of CNHs is retained in the chimeric materials, suggesting that the interactions with the liposomes do not alter the dahlia-flower-like aggregation of CNHs. Both CNHs-liposome systems exhibit a relatively small cellular cytotoxicity in vitro, tested in mouse embryonic fibroblasts. To summarize, we developed CNHs:liposome platforms with a complete knowledge of their thermotropic, physicochemical, morphological and nanotoxicological characteristics.

 

 

There is an emerging need to evolve the conventional lyotropic liquid crystalline nanoparticles to advanced stimuli-responsive, therapeutic nanosystems with upgraded functionality. Towards this effort, typically used stabilizers, such as Pluronics®, can be combined or replaced by smart, stimuli-responsive block copolymers. The aim of this study is to incorporate the stimuli-responsive amphiphilic block copolymer poly(2-(dimethylamino)ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA) as a stabilizer in lipidic liquid crystalline nanoparticles, in order to provide steric stabilization and simultaneous stimuli-responsiveness. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by light scattering techniques, cryogenic-transmission electron microscopy (cryo-TEM), X-ray diffraction (XRD) and fluorescence spectroscopy. The PDMAEMA-b-PLMA, either individually or combined with Poloxamer 407, exhibited different modes of stabilization depending on the lipid used. Due to the protonation ability of PDMAEMA blocks in acidic pH, the nanoparticles exhibited high positive charge, as well as pH-responsive charge conversion, which can be exploited towards pharmaceutical applications. The ionic strength, temperature and serum proteins influenced the physicochemical behavior of the nanoparticles, while the polymer concentration differentiated their morphology; their micropolarity and microfluidity were also evaluated. The proposed liquid crystalline nanosystems can be considered as novel and attractive pH-responsive drug and gene delivery nanocarriers due to their polycationic content.