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The Laboratory of Pharmaceutical Nanotechnology (Demetzos Lab) belongs to the Section of Pharmaceutical Technology of the Department of Pharmacy of the School of Health Sciences, National and Kapodistrian University of Athens (UoA). It is oriented in the area of applied nanotechnology, especially targeted drug delivery nanosystems and colloidal nanocarriers for therapeutic purposes. The lab has been and continues to be a participant in many international, european and national research programs. It is also in close collaboration with scientists and academic partners from institutions all over the world, as well as with a number of industries, aiming to produce scientific evidence that will aid the development and approval of innovative nanoproducts. It is also an active member of many scientific societies. Its director is Professor Costas Demetzos.

  

 

 

Recent News

 

COSTAS N. DEMETZOS

PROFESSOR

ACADEMY OF ATHENS 2018 AWARD

 

Costas N. Demetzos, Professor of Pharmaceutical Technology & Nano-Technology, Department of Pharmacy of the National & Kapodistrian University of Athens, was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology. The ceremony took place during the formal sitting on the 21th of December, 2018 in the Great ceremony hall of the Academy of Athens, after the unanimous decision of the Athens Academy Plenary. The President of the Academy of Athens, Academician Antonios Kounadis presented the award to the honored Professor.

 

 

 

Νέο Βιβλίο του Καθηγητή Κ. Δεμέτζου

Κυκλοφορεί από τις Εκδόσεις Παρισιάνου

 

Ο συγγραφέας περιγράφει με λογοτεχνικό τρόπο την ‘συνομιλία’ ανάμεσα στον μικρόκοσμο και στον μακρόκοσμο μέσα από μια φανταστική συζήτηση ενός νεαρού επιστήμονα με τον ‘παππού’ και τον φανταστικό ‘καθρέφτη’ της αυτογνωσίας. Η συζήτηση εξελίσσεται μέσα σε μια βιβλιοθήκη και βασίζεται στα σημαντικά επιτεύγματα της επιστήμης αλλά και της φιλοσοφίας τα οποία ο νεαρός επιστήμονας προσπαθεί να κατανοήσει. Ο συγγραφέας προσπαθεί να μεταφέρει μέσω της συζήτησης, την εξέλιξη των φυσικών νόμων που συμβαίνουν στον μικρόκοσμο, ως τα αληθινά ‘γεγονότα’ τα οποία εμείς προσπαθούμε να κατανοήσουμε στον μακρόκοσμο, με βάση τα επιστημονικά εργαλεία και την φιλοσοφική σκέψη που διαχρονικά έχουμε κατακτήσει ως ανθρώπινα όντα. Η συζήτηση είναι ελκυστική και βαθιά επιστημονική με αναφορές στην βιοφυσική και βιο-θερμοδυναμική, στην χημεία και στην πολυπλοκότητα των βιο-συστημάτων και βιο-δικτύων, ενώ η φιλοσοφία λειτουργεί ως εργαλείο ανάδειξης των ανθρώπινων αδυναμιών μας να κατανοήσουμε την έννοια της δημιουργίας και της κτίσης. Η κοινωνία ως αποδέκτης όλων των μεταβολών και εξελίξεων του μικρόκοσμου αποτελεί την αρένα της εξέλιξης των ‘γεγονότων’ του μικρόκοσμου στον μακρόκοσμο. Μια συνεχής και αέναη προσπάθεια χωρίς τέλος προτείνεται από τον συγγραφέα για την κατάκτηση της επιστημονικής γνώσης και της δημιουργικής προσφοράς του ανθρώπου στην κοινωνία και στον συνάνθρωπο.

 

 

 

Honorary Award to Professor Costas Demetzos
Best in Pharmacy Awards 2019

 

Honorary Best in Pharmacy award from Boussias Communications and from the journal Pharmaceutical World to Professor Costas Demetzos for his significant contribution in the Pharmaceutical Science.

 

 

 

PhD Thesis Presentation and Graduation of Nikolaos Naziris

 

Nikolaos Naziris, Pharmacist, MSc, was granted the title of Doctor of Philosophy in Pharmaceutical Sciences with the highest honors on July 15th. His PhD research regards the "Design, Technological Development and Evaluation of Stimuli-responsive Chimeric Nanocarriers for Cancer Therapy".

 

 

Honorary Award Ceremony to Professor Costas Demetzos
14th PanCretan Pharmaceutical Congress

 

Honorary award with gratitude, from the Pharmaceutical Associations of Crete to Professor Costas Demetzos for his significant contribution and recognition in Pharmaceutical Science, in Greece and internationally. The ceremony took place during the 14th PanCretan Pharmaceutical Congress in Sisi of Lasithi, Crete, Greece, May 2019.

In the picture, we may see from left to right I. Tsikandalakis, M. Fouledakis, Prof. C. Demetzos, K. Kaldis and K. Vardiabasis.

 

 

 

 

Latest Publications

 

Nanomedicines and Nanosimilars: Looking for a New and Dynamic Regulatory "Astrolabe" Inspired System


 

The application of the nanotechnology in medicine and pharmaceutics opens new horizons in therapeutics. Several nanomedicines are in the market and an increasing number is in clinical trials. But which is the advantage of the medicines in nanoscale? The scientists and the regulatory authorities agree that the size and consequently the physiochemical/biological properties of nanomaterials play a key role in their safety and effectiveness. Additionally, all of them agree that a new scientific-based regulatory landscape is required for the establishment of nanomedicines in the market. The aim of this review is to investigate the parameters that the scientists and the regulatory authorities should take into account in order to build up a dynamic regulatory landscape for nanomedicines. For this reason, we propose an “astrolabe-like system” as the guide for establishing the regulatory approval process. Its function is based on the different physicochemical/biological properties in comparison to low molecular weight drugs.

 

Physicochemical, morphological and thermal evaluation of lyotropic lipidic liquid crystalline nanoparticles: The effect of stimuli-responsive polymeric stabilizer

  

 Non-lamellar liquid crystalline nanoparticles are promising drug delivery lipidic nanosystems, stabilized by amphiphilic block copolymers. In the present investigation, the widely used Poloxamer P407 is compared with the innovative stimuli-responsive polycationic block copolymer poly(2-(dimethylamino)ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA) as stabilizer for glyceryl monooleate (GMO) or phytantriol (PHYT)-based colloidal dispersions of liquid crystalline nanoparticles. As such, a variety of techniques was combined in order to comprehensively characterize these nanosystems in terms of physicochemical, morphological and thermal properties. Particle size, size distribution, ζ-potential and the fractal dimension parameter (df), calculated from light scattering data, as well as the morphology (from cryo-TEM analysis) of nanoparticles were markedly affected by the different lipid and type of polymeric stabilizer, indicating different kind of interfacial lipid-polymer interactions. Notably, PDMAEMA-b-PLMA block copolymer was effective as well as P407 in stabilizing the GMO-based, but not PHYT-based nanosystems. Furthermore, microcalorimetry, high-resolution ultrasound spectroscopy and rheology were applied to characterize the thermal behavior of these nanosystems, highlighting their transition temperatures. In conclusion, a detailed evaluation was carried out on liquid crystalline nanoparticles, providing significant information, useful for the development of innovative non-lamellar therapeutic nanosystems with advanced properties that can be successfully applied in the pharmaceutical nanotechnology field.

 

pH-responsive chimeric liposomes: From nanotechnology to biological assessment

 

The utilization of liposomes in biomedical applications has greatly benefited the diagnosis and treatment of various diseases. These biomimetic nano-entities have been very useful in the clinical practice as drug delivery systems in their conventional form, comprising lipids as structural components. However, the scientific efforts have recently shifted towards the development of more sophisticated nanotechnological platforms, which apply functional biomaterials, such as stimuli-responsive polymers, in order to aid the drug molecule targeting concept. These nanosystems are defined as chimeric/mixed, because they combine more than one different in nature biomaterials and their development requires intensive study through biophysical and thermodynamic approaches before they may reach in vivo application. Herein, we designed and developed chimeric liposomes, composed of a phospholipid and pH-responsive amphiphilic diblock copolymers and studied their morphology and behavior based on crucial formulation parameters, including biomaterial concentration, dispersion medium pH and polymer composition. Additionally, their interactions with biological components, pH-responsiveness and membrane thermodynamics were assessed. Finally, preliminary in vivo toxicity experiments of the developed nanosystems were carried out, in order to establish a future protocol for full in vivo evaluation. The results have been correlated with the properties of the chimeric nanosystems and highlight the importance of such approaches for designing and developing effective nanocarriers for biomedical applications.